Ethyl biscoumacetate

Ethyl biscoumacetate

Systematic (IUPAC) name
ethyl 2,2-bis(4-hydroxy-2-
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	548-00-5^N
ATC code	B01AA08
PubChem	CID 11047
DrugBank	DB08794
ChemSpider	10444159^Y
UNII	08KL644731^N
KEGG	D07131^Y
Chemical data
Formula	C₂₂H₁₆O₈
Mol. mass	408.358 g/mol
InChI InChI=1S/C22H16O8/c1-2-28-20(25)15(16-18(23)11-7-3-5-9-13(11)29-21(16)26)17-19(24)12-8-4-6-10-14(12)30-22(17)27/h3-10,15,23-24H,2H2,1H3^Y Key:JCLHQFUTFHUXNN-UHFFFAOYSA-N^Y
N(what is this?) (verify)

Ethyl biscoumacetate is a vitamin K antagonist.

References

The Merck Index, 12th Edition. 3818

Antithrombotics (thrombolytics, anticoagulants and antiplatelet drugs) (B01)

Antiplatelet drugs

Glycoprotein IIb/IIIa inhibitors	Abciximab • Eptifibatide • Tirofiban

ADP receptor/P2Y₁₂ inhibitors	thienopyridines (Clopidogrel, Prasugrel, Ticlopidine) • nucleotide/nucleoside analogs (Cangrelor, Elinogrel, Ticagrelor)

Prostaglandin analogue (PGI2)	Beraprost • Prostacyclin • Iloprost • Treprostinil

COX inhibitors	Acetylsalicylic acid/Aspirin^# • Aloxiprin • Carbasalate calcium • Indobufen • Triflusal

Thromboxane inhibitors	thromboxane synthase inhibitors (Dipyridamole, Picotamide) • receptor antagonist (Terutroban^†)

Phosphodiesterase inhibitors	Cilostazol • Dipyridamole • Triflusal

Other	Cloricromen • Ditazole

Vitamin K antagonists
(inhibit II, VII, IX, X)

coumarins: Acenocoumarol • Coumatetralyl • Dicoumarol • Ethyl biscoumacetate • Phenprocoumon • Warfarin^#

1,3-Indandiones: Clorindione • Diphenadione • Phenindione

other: Tioclomarol

Factor Xa inhibitors
(with some II inhibition)

Heparin group/ glycosaminoglycans/ (bind antithrombin)	low-molecular-weight heparin (Bemiparin, Certoparin, Dalteparin, Enoxaparin, Nadroparin, Parnaparin, Reviparin, Tinzaparin) oligosaccharides (Fondaparinux, Idraparinux) heparinoid (Danaparoid, Sulodexide, Dermatan sulfate)

Direct Xa inhibitors	xabans (Apixaban, Betrixaban, Edoxaban, Otamixaban, Rivaroxaban)

Direct thrombin (II) inhibitors

bivalent: Hirudin (Bivalirudin, Lepirudin, Desirudin)

univalent: Argatroban • Dabigatran • Melagatran^‡ • Ximelagatran^‡

Other

REG1 • Defibrotide • Ramatroban • Antithrombin III • Protein C (Drotrecogin alfa)

Thrombolytic drugs/
fibrinolytics

plasminogen activators: r-tPA (Alteplase, Reteplase, Tenecteplase) • UPA (Urokinase, Saruplase) • Streptokinase^# • Anistreplase • Monteplase

other serine endopeptidases: Ancrod • Fibrinolysin

Citrate • EDTA • Oxalate

^#WHO-EM. ^‡Withdrawn from market. Clinical trials: ^†Phase III. ^§Never to phase III

M: MYL

cell/phys (coag, heme, immu, gran), csfs

rbmg/mogr/tumr/hist, sysi/epon, btst

drug (B1/2/3+5+6), btst, trns

Types of coumarins

Aglycones	Aesculetin \| Dicoumarol \| Ferujol \| Herniarin \| Hymecromone \| Osthol \| Scopoletin \| Umbelliferone

glycosides	Aesculin \| Skimmin (7-O-β-D-glucopyranosylumbelliferone) \| Scopolin

Furan derivatives	Furanocoumarins (Angelicin \| Apterin \| Bergamottin \| Bergapten \| Imperatorin \| Marmesin \| Methoxsalen \| Psoralen \| Trioxsalen) \| Furanochromones

Monoterpene coumarin ether	Auraptene

Synthetic or drugs	Acenocoumarol \| Coumatetralyl \| Ensaculin \| Ethyl biscoumacetate \| 4-Hydroxycoumarins \| Phenprocoumon \| Warfarin